Abstract
1068 We evaluated the influence of central command on carotid-cardiac baroreflex function during steady state dynamic exercise. Five subjects (26±2 yrs) performed dynamic exercise at 20% V̇O2max for seven minutes. Each subject performed the exercise bout under two conditions: control and partial neuromuscular blockade using Norcuron (curare). Heart rate (HR; beats/min) and mean arterial pressure (MAP; mmHg) were measured throughout. Carotid baroreflex function (CBR) was recorded using a pulsed neck pressure/neck suction technique. Cardiac responses were used to model CBR curves. Threshold (TH), saturation (SAT), gain, range (RR) and minimum response (HRmin) were defined. Increased central command with curare significantly elevated MAP (117.6±5) and HR (112.8±6) from control MAP (92.3±5) and HR (98.5±6) during dynamic exercise (P<0.05). (Table)TableThe results indicate that the feed-forward efferent neural input from central command actively regulates the carotid baroreflex during low intensity dynamic exercise. Supported by Copenhagen Muscle Research Center
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