Abstract
Objective To determine the antiobesity effects of Panax ginseng in animals. Methods We conducted a systematic search for all controlled trials (up to March 2017) that assessed the antiobesity effects of P. ginseng in animal obesity models in the PubMed, EMBASE, Cochrane library, Web of Science, and Scopus databases. The primary outcome was final body weight measured at the longest follow-up time after administration of the intervention. The secondary outcome was the lipid profile. We assessed methodological quality using the SYRCLE risk of bias tool, and RevMan 5.3 was used to perform a meta-analysis. Finally, a subgroup analysis of parameters including intervention duration, animal models, and type of ginseng was performed. Result We identified 16 studies that met the inclusion criteria. Data from the meta-analysis indicated that the intervention group had a significantly lower body weight than the control group (SMD: −1.50, 95% CI: −1.90 to −1.11, χ2: 78.14, P < 0.0001, I2 = 58%). Final body weight was lower in an animal obesity model induced by high-fat diet than in genetic models. Also the intervention group had a significantly higher serum HDL level and lower serum LDL, TG, and TC level than the control group. Conclusion Our meta-analysis indicated that oral administration of P. ginseng significantly inhibits weight gain and improves serum lipid profiles in animal obesity models. However, causes of obesity and type of ginseng may affect treatment effects.
Highlights
The worldwide prevalence of obesity has increased significantly in recent decades [1]
Numerous variants of gichonseng have many of the same compounds and medicinal properties, we focused on P. ginseng C.A
This review describes the experimental details of P. ginseng administration in studies using different species and strains of animals
Summary
The worldwide prevalence of obesity has increased significantly in recent decades [1]. The treatment of obesity using conventional medication has numerous limitations, including adverse effects of medication and the potential for drug abuse [5, 6]. Interest in complementary and alternative therapies for the treatment of obesity has been increasing globally [7, 8]. Panax ginseng has been shown to exert several pharmacological and physiological effects. These include beneficial effects against cancer [10], hypertension [11], diabetes [12], nociception [13], and stroke [14], as well as reported improvements in chronic fatigue [15]. It has been reported to exert antiobesity effects [16, 17]
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