Abstract
No effective, reliable treatment for stomatitis associated with cancer therapy has been established. This study focused on the its effectiveness of ozone nano-bubble water (ONBW) for the treatment of chemotherapy-induced stomatitis. Oral mucositis was induced in 14-week-old male Sprague-Dawley rats (N = 21). The animals were randomly divided into 3 groups: 7 without treatment (control); 7 treated with physiological salt solution (saline); and 7 treated with ONBW. Animals were weighed on Days 7, 9, 11, and 16. Stomatitis grade evaluation and bacterial count measurements were performed before rinsing in all animals 3, 5, and 10 days after acetic acid irritation (Days 9, 11, and 17 respectively). Weight loss after stomatitis creation was observed in all groups, with significant differences between the control and ONBW groups and between the saline and ONBW groups on Day 16. The stomatitis grade did not worsen during the experimental period in any group, with the lowest grades in the ONBW group on Days 11 and 16. Significant differences were identified between the control and ONBW groups and between the saline and ONBW groups on Days 11 and 16. Oral bacterial counts tended to decrease over time in all three groups, with the greatest decrease in the ONBW group, followed by the saline group. The decrease in the bacterial count was steepest in the ONBW group. Rinsing out the oral cavity with ONBW decreased bacterial counts and encouraged the healing of oral chemotherapy-induced stomatitis. ONBW may be an effective treatment for chemotherapy-induced stomatitis.
Highlights
Cancer treatment has made great strides with the development of new anticancer agents and combination radiotherapy protocols [1].Compared with the development of therapies for primary disease, the development of treatments for the side effects associated with these therapies is lagging [2]
The secondary cause is the adhesion of high levels of oral bacteria to the ulcerated surface, causing local infection on the mucosal surface, and, in combination with the metabolic damage and susceptibility to infection caused by anticancer agents, this can become intractable or serious [9,10]
This study focused on ozone nano-bubble water (ONBW) [20,21], which has previously been shown to have a range of effects, including antibacterial effects [17], promotion of wound healing [18], an antiinflammatory effect [18], and a hemostatic effect [19], and its effectiveness in the treatment of chemotherapy-induced stomatitis was investigated
Summary
Cancer treatment has made great strides with the development of new anticancer agents and combination radiotherapy protocols [1].Compared with the development of therapies for primary disease, the development of treatments for the side effects associated with these therapies is lagging [2]. It has been reported that oral mucositis is a common side effect in patients receiving anticancer agents, with an incidence of 25%–55% in patients receiving anticancer agents for solid cancer, 70%–90% in those receiving high-dose anticancer agents for hematopoietic stem cell transplantation, and almost 100%. ∗. In general, the etiology of chemotherapy-induced stomatitis can be broadly divided into two main causes. One primary cause is mucosal inflammation due to the destruction of the cells that compose the oral mucosa by reactive oxygen species (superoxide or hydroxy radicals) generated by anticancer agents. The secondary cause is the adhesion of high levels of oral bacteria to the ulcerated surface, causing local infection on the mucosal surface, and, in combination with the metabolic damage and susceptibility to infection caused by anticancer agents, this can become intractable or serious [9,10]. Stomatitis is being studied using a range of different animal models [11], but the detailed etiology of chemotherapy-induced stomatitis is unknown and may be more complex [12–14]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
