Abstract
Effect of oral calcium load on calcium metabolism was studied in 6 healthy subjects. Calcium carbonate (3.75 g) and Oyster Shell Electrolysate (OSE, 3.0 g) were orally administrated in a cross-over design to provide 1.5 g elementary calcim to each subject twice at 1 week interval. No significant differences were found in the increments of serum calcium, blood ionized calcium and urinary calcium excretion and in the decrements of serum PTH and urinary phosphorus excretion. The decrease in serum phosphorus level after OSE administration, however, was significantly greater than that after calcium carbonate administration. OSE thus appears to have a more potent phosphate binding capacity than calcium carbonate despite indistinguishable immediate effects on the increments of serum calcium and suppression of serum PTH. OSE may therefore represent a new candidate for a potent phosphate binder with a prospect for replacing calcium carbonate currently on use in chronic renal failure.
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