Abstract
Background and AimsFatty liver increases oxidative stress and may trigger antioxidant mechanisms. We aimed to compare the levels of vitamin D, which has antioxidant properties, as well as total oxidant status (TOS), total antioxidant status (TAS), and catalase between patients with nonalcoholic fatty liver (NAFL) and the control group.MethodsWe compared vitamin D, TOS, TAS, catalase levels, and other biochemical parameters between pediatric patients with ultrasonographically detected NAFL and an age-matched healthy control group.ResultsNAFL patients had a significantly lower vitamin D level (p < 0.001). The patient group also had significantly greater height, weight, body mass index (BMI) Z score, parathyroid hormone, triglyceride, glucose, antioxidant (TAS and catalase), and TOS levels compared to the controls (p ≥ 0.001). There was no significant difference between the obese and non-obese NAFL patients with respect to TAS, TOS, catalase levels, and other biochemical parameters (p < 0.05). There was a positive correlation between height, weight, BMI Z score, and hepatosteatosis grade, and TAS, TOS, and catalase levels, and a negative correlation with vitamin D level. We also found a negative correlation between vitamin D level and TOS and catalase level.ConclusionsOur study revealed lower levels of vitamin D and higher levels of oxidant-antioxidants including TOS, TAS, and catalase in patients with NAFL.
Highlights
Nonalcoholic fatty liver disease (NAFLD) is one of the common chronic liver disorders in children
The patient group had significantly greater height, weight, body mass index (BMI) Z score, parathyroid hormone, triglyceride, glucose, antioxidant (TAS and catalase), and total oxidant status (TOS) levels compared to the controls (p ≥ 0.001)
There was a positive correlation between height, weight, BMI Z score, and hepatosteatosis grade, and total antioxidant status (TAS), TOS, and catalase levels, and a negative correlation with vitamin D level
Summary
Nonalcoholic fatty liver disease (NAFLD) is one of the common chronic liver disorders in children It is characterized by elevated biochemical markers due to injury occurring secondary to hepatic fat accumulation. Patients with hepatosteatosis show an increased level of oxidative stress and impaired antioxidant defense mechanisms [5]. We aimed to compare admission vitamin D and antioxidant levels between pediatric patients with ultrasonographically detected fatty liver and the control group in order to contribute to the. We aimed to compare the levels of vitamin D, which has antioxidant properties, as well as total oxidant status (TOS), total antioxidant status (TAS), and catalase between patients with nonalcoholic fatty liver (NAFL) and the control group
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