Abstract
AbstractThe ability of estradiol (E) and progesterone (P) to act as luteotrophins in place of LH was investigated in pseudopregnant (PSP) rats. The length of PSP was extended by either hysterectomy (hyst.) or by the experimental induction of decidual tissue (DT) on Day 5 (Day 1 = ovulation). On Day 9, LH was removed from circulation by a sc injection of a specific LH antiserum (LHAS) and each rat was simultaneously treated with various dosages of E and/or P. Control rats were treated with normal horse serum (NHS) and/or oil vehicle. Blood samples were collected at 0, 24, and 72 hr post-treatment for the estimation of serum P levels. Day 5 hyst. rats treated with any dose (0.1 − 10.0 μg) of E or P (2 mg), alone or in combination, and simultaneously injected with NHS or LHAS exhibited elevated P levels through Day 12 and an extended diestrous cycle. In contrast, oil-treated, LHAS-injected rats underwent immediate luteolysis. DT-bearing PSP rats treated with 10 μg of E failed to undergo luteolysis following ...
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