Abstract

SUMMARY Histochemical studies showed that during the rat oestrous cycle, uterine epithelial lipids were at their highest levels during dioestrus and pro-oestrus. In ovariectomized mature animals given oestradiol-17β, either by itself or in combination with medroxyprogesterone acetate, neutral lipids and unsaturated lipids were below control levels, while phospholipids were increased. Medroxyprogesterone acetate, however, increased levels of neutral lipids and unsaturated lipids, and decreased phospholipids. It is suggested that during the oestrous cycle of the rat, high concentrations of uterine epithelial lipid during late dioestrus and pro-oestrus reflect the increased plasma progesterone of early dioestrus acting in a low plasma oestrogen environment.

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