Effects of osteoarthritis on age-at-death estimates from the human pelvis.

Abstract

This study examined the degree of error in age-at-death estimates when osteoarthritis (OA) is present in three separate pelvic joint areas: (1) the pubic symphysis, (2) the auricular surface, and (3) the acetabulum from a modern known-age European cemetery sample of adults. Age-at-death ranged from 17 to 79 years (x̄ =50.9 years; n = 252). OA in the pelvic joints was evaluated using standard ranked categorical scoring. Composite OA scores were derived through principal component analysis. Blind age assessments and all analyses were performed separately by region. Error between adult age groups (young, middle, old) and between OA severity groups (low, middle, high) was evaluated using one-way ANOVAs with post-hoc testing, ordinary least squares regression, and transition analysis with a cumulative probit model. Ages-at-transition were compared with Nphases2. Three significant results emerge. First, OA severity has an effect on the accuracy of age estimates from os coxa joints in this sample. Second, this influence is most significant for different age cohorts in each joint region, demonstrating that varied rates of arthritic trait progression occur between the auricular surface, pubic symphyses, and acetabulum. Third, those with OA appear to be aging faster, a consistent trend among the os coxa regions. These results have significant consequences for understanding the rate of bone remodeling in relation to disease, aging, and the evaluation of skeletal age indicators.