Abstract
Oryeongsan (ORS) which was first recorded in SangHanLoon, the classic of traditional Chinese medicine describing treatments of disordered body fluid balance. Renal hypertension is caused by renovascular dysfunction through an activation of renin‐angiotensin‐aldosterone system (RAS). The RAS is one of the most important regulators in maintenance of body fluid homeostasis and in long‐term regulation of blood pressure. The purpose of this study is to identify effects of ORS on regulation of renal function, change of blood pressure and RAS in the two‐kidney one‐clip (2K1C) renal hypertensive rats. Experiments were performed in four experimental groups: sham rats, 100 mg/kg/day ORS in sham rats, 2K1C rats and ORS in 2K1C rats, respectively. After 4 weeks of operation, sham and 2K1C rats were administered with vehicle or ORS for 3 weeks. Urinary volume, urinary excretion of Na+, K+, Cl−, osmolality and creatinine were measured. The 2K1C rats showed significantly higher systolic blood pressure (SBP) compared with sham rats. ORS treatment for 3 weeks markedly decreased the SBP in 2K1C rats. ORS significantly increased urinary volume, urinary excretion of electrolytes, and clearance of creatinine (CCr) in 2K1C rats. ORS significantly suppressed plasma level of PRA, Angiotensin II and aldosterone in 2K1C rats. Also, ORS suppressed the upregulated RAS components in the kidney from 2K1C rats. However, ORS increased plasma level of ANP in 2K1C rats. These findings suggest that ORS may elicit renal and vascular effects via two ways: directly and indirectly through activation of the ANP system and inhibition of the RAS.Support or Funding InformationThis abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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