Abstract
The antifertility activity of organoantimony(III) complexes PhSb[RC(NC6H4S)CH2(NC6H4S)CR′] {R' = CH3 (R1) and R = R' = CF3 (R2)} derived from corresponding sterically hinlered bifuinctional tetradentate ligands in the male rats was determined. The administration of compounds R1 and R2 at the dose level of 20 mg/kg. b. wt. siignificantly reduced the weights of testes and epididymides. Auxiliary glands showed a significant reduction after the treatment of compound R1 only. Treated animals showed a notable depression of spermatogenesis. The preleptotene spermatocytes were decreased by 76.19 and 47.06; the secondary spermatocytes by 87.4% and 54.87337; and the step-19 spermatids by 72.9 and 46.77% respectively, following the compound R1 and R2 treatment. Reduced sperm count and motility resulted in 100% negative fertility in both the treated groups. A significant fall in the content of various biochemical parameters of eproductive tissues was observed after R1 and R2 treatment in comparison to controls.
Highlights
A large number of antimony(Ill) compounds have been tested as bactericides[l] and fungicides[2].The pharmacological activity of antimony compounds has developed ever since the advent of rational chemotherapy [3,4]
A number of antimony compounds have been found most effective against various diseases [5]
The rate of implantation was lowered and reduction in litter size have been reported by some phenothiazine derivatives [9,10]
Summary
A large number of antimony(Ill) compounds have been tested as bactericides[l] and fungicides[2].The pharmacological activity of antimony compounds has developed ever since the advent of rational chemotherapy [3,4]. Introduction A large number of antimony(Ill) compounds have been tested as bactericides[l] and fungicides[2]. A number of antimony compounds have been found most effective against various diseases [5]. The survey of the literature revealed that no attention has been paid to the activity of these compounds on the reproductive system of male rats.
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