Abstract
A highly purified ethyl ester of EPA (EPAEE) (74%) was manufactured from sardine oil. Sixty mg/kg/day of EPAEE was given orally to male Wishar rats for 8 weeks. No side effect or toxicity from the administration of EPAEE was observed. Plasma EPA concentration and the ratio of EPA to arachidonic acid were significantly increased, compared with control Wistar rats. An enhancement of PGI 2-like substance production by aortas obtained from rats fed EPAEE was noted. Conversion of EPA to Λ 17-6-keto-PGF 1α, a stable metabolite of PGI 3, could not be detected by an incubation study of 14C-EPA and aortas either from rats fed EPAEE or from control rats. Therefore, PGI 2-like substance produced by rat aorta is most likely to be PGI 2. itself and not PGI 3.
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