Abstract
Daily oral doses of 10, 20, 50 and 75μg of ethinylestradiol were administered for three weeks to groups of normal healthy women. Changes in blood levels of albumin, ceruloplasmin, total iron-binding capacity, haptoglobin and orosomucoid were followed. The estrogen decreased serum albumin, haptoglobin and orosomucoid, increased ceruloplasmin, but had no effect on iron-binding capacity. There was no significant difference in these components between the 50 and 75 μg daily oral doses, and differences between 20 and 50 μg doses were small in most cases. The concurrent administration of 1.0 or 3.0 mg daily of norethisterone acetate with the 50μg daily dose of ethinylestradiol had little extra effect on the serum proteins, with the exception of total iron-binding capacity, which showed a marked increase.
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