Abstract
BackgroundWe used a network meta-analysis of randomized controlled trials (RCTs) to comparatively examine the effects of oral antidiabetic drugs (OADs) on left ventricular mass (LVM) in patients with type 2 diabetes.MethodsDocument searches were implemented using Medline, Cochrane Controlled Trials Registry, and ClinicalTrials.gov. We decided to include RCTs that evaluated the impact of LVM using the administration of OADs to patients with type 2 diabetes. The outcome evaluations used standardized mean difference (SMD) and 95% confidence intervals (CIs). We then performed a comparative examination of LVM related to the administration of OADs using random effects network meta-analysis.ResultsThe document search found 11 RCTs (1410 people) that satisfied the eligibility criteria for this study, and these RCTs were incorporated into the network meta-analysis. The only medication that significantly reduced LVM compared to a placebo was gliclazide (SMD, −1.09; 95% CI, −1.62 to − 0.57). Further, when comparing the impact on LVM between OADs, only gliclazide significantly reduced LVM compared to other OADs (glyburide, voglibose, metformin, pioglitazone, rosiglitazone, and sitagliptin).ConclusionsIn the present study, gliclazide was the only medication that significantly reduced LVM in patients with type 2 diabetes. When considered from the perspective of causing heart failure and preventing recurrence, it is possible that the use of gliclazide in patients with type 2 diabetes will provide multiple benefits.
Highlights
We used a network meta-analysis of randomized controlled trials (RCTs) to comparatively examine the effects of oral antidiabetic drugs (OADs) on left ventricular mass (LVM) in patients with type 2 diabetes
The purpose of this research is to use RCT network meta-analysis to examine the impact of the administration of OADs on LVM in patients with type 2 diabetes
The search strategy was implemented by multiplying the search formulas for type 2 diabetes, OADs, and RCTs (Appendix 1)
Summary
We used a network meta-analysis of randomized controlled trials (RCTs) to comparatively examine the effects of oral antidiabetic drugs (OADs) on left ventricular mass (LVM) in patients with type 2 diabetes. Cardiovascular disease in patients with type 2 diabetes is linked to increased risk of death, which is an extremely important clinical outcome [1]. An increase in heart failure among patients with type 2 diabetes has become a grave issue, and the prevention and management of heart disease has become an important focus [2]. Several OADs have the following effects: anti-inflammatory, anti-oxidation, vascular protection, and suppression of myocardial fibrosis. They are thought to possibly reduce LVM [2, 13]. Some reports have shown no significant LVM reduction upon the administration of OADs [17,18,19] and inconsistent effects
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