Abstract
1. 1. Superfusion of cultured hippocampal cells with glutamate (Glu) 0.5 mM for 5 min induces an increase of [Ca 2+ i] that is quickly followed by a recovery to control level. Addition of dynorphin or D-pen 2-D-pen 5-enkephalin (DPDPE) induces a persistence of the elevated [Ca 2+ i], while [D-Ala 2,N-Me-Phe 4, Gly 5-ol]-enkephalin (DAMGO) does not influence it. 2. 2. Superfusion with Glu for 10 min induces a persistent increase of [Ca 2+ i], that is partially reverted by DAMGO, but not affected by dynorphin or DPDPE. 3. 3. The author suggests a differential influence of selective opioids on the Glu-induced [Ca 2+ i] increase.
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