Effects of onion peel extract on body composition changes in overweight Korean adults (1031.1)

Abstract

Anti‐obesity effects of quercetin‐rich onion peel extract (OPE) were suggested in rats, but the information from human studies was limited. This study was performed to investigate the effects of OPE on body composition in overweight subjects.This study was conducted a 12‐week, randomized, double blinded, placebo‐controlled, parallel clinical trials in overweight Korean subjects (BMI 26.5±3.0 kg/m2). Randomly assigned subjects were instructed to take either the placebo (male 6, female 30) or 100 mg quercetin‐OPE capsules each day (male 5, female 31). Body composition was measured by bioimpedance and dual X‐ray absorptiometry (DXA) methods. Resting energy expenditure (REE) and respiratory quotient (RQ) were evaluated by indirect calorie methods. Fasting blood levels of glucose, insulin, lipids, leptin, visfatin, and adiponectin were determined. Urinary malondialdehyde (MDA) was measured at baseline and after quercetin supplementation.Quercetin‐rich OPE supplementation significantly reduced weight and body fat percents measured by DXA (p < 0.05), whereas these effects were not shown in the placebo group. Blood glucose, leptin, and urinary MDA were decreased in both groups (p<0.05). Significant increases were observed in REE and blood levels of adiponectin in both groups (p < 0.05).Quercetin‐rich OPE changed body composition in overweight subjects, and this results suggested a beneficial role for quercetin as anti‐obesity effects in human subjects.Grant Funding Source: Supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forest