Abstract
To evaluate the effects of the use of omega 3 at different doses, following the response through stereological and morphometric evaluations in doxorubicin-induced acute cardiotoxicity in an experimental rabbit model. Thirty healthy adult New Zealand rabbits were divided into six groups with different doses of omega 3 treatment, GT125, GT500 and GT 2000, receiving doses of 125mg / kg, 500mg / kg and 2000mg / kg, respectively. The induction of acute cardiotoxicity with doxorubicin was treated for six days prior to intravenous administration of 10mg / kg single dose. Then, the animals were euthanized and myocardial samples were collected for stereological and morphometric evaluations. The stereological evaluation showed an increase in the transverse area of cardiomocytes between the SHAM and GT2000 groups and an increase in the interstitial collagen volume density between the SHAM and GT500 and SHAM and GT2000 groups. The omega 3 500mg/kg dose has the potential to attenuate the fibrotic effects of doxorubicin use and the use of a single dose of 10mg/kg doxorubicin can be used as an acute dilated cardiomyopathy induction protocol in an experimental model using rabbits.
Highlights
Doxorubicin is a chemotherapy agent widely used in the oncology routine in humans, and no different in veterinary medicine
This study aimed to evaluate the cardioprotective effects of the use of omega 3 at different doses, following the response in electrocardiographic evaluations and through stereological and morphometric analyzes in acute cardiotoxicity in an experimental model with rabbits
Mortality The mortality rate was calculated only in GT125 where 100% of the animals included in the group died, making it impossible to evaluate after 48 hours of doxorubicin induction
Summary
Doxorubicin is a chemotherapy agent widely used in the oncology routine in humans, and no different in veterinary medicine It is an anthracycline drug, indicated for the treatment of hematologic neoplasms, carcinomas, primary lung tumors, among others (Luu et al 2018, Olson et al 1978). With the advancement of clinical specialties, oncology is the area that receives great attention in the development of new diagnostic and therapeutic techniques favoring that children have a survival rate of 70% after tumor diagnosis. To achieve this success, the essential drug in the therapeutic protocol is doxorubicin, but long-term toxicity is the main concern for maintaining patients' quality of life (Curry et al 2006). Injury to cardiomyocytes occurs due to non-selectivity of the chemotherapeutic agent to cancer cells (Luu et al 2018, Curry et al 2006)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
