Abstract
Background and Aims: Hyperlipidemia is one of clear risk factors of diabetes. Regarding its importance, this study was designed to compare the effects of olive oil and grape seed oil on serum lipids and blood pressure in patients with hyperlipidemia in 2015. Methods and Results: In this clinical trial, 60 patients with hyperlipidemia who met inclusion criteria were recruited. Subjects were randomly assigned 3 groups: 1) consume 20 ml/day refined olive oil; 2) consume 20 ml/day grape seed oil; 3) the control group received no oil. The study period was six weeks. All participants were under Step I diet. Height and weight measurements were taken by Seca scale. Blood pressure, total cholesterol, high-density lipoprotein, triglyceride and fasting blood sugar were measured at baseline and after 6 weeks by standard methods. Low-density lipoprotein levels were calculated by the Friedewald’s formula. Data were analyzed with ANOVA test in SPSS software version 16.0. Sixty participants (36 female and 24 male) with the average age of 47.5 ± 9 y and the mean body mass index of 31.78 ± 5.41 kg/m2 had completed the study. Olive oil intervention decreased systolic blood pressure significantly compared to grape seed oil group (P = 0.01). Triglyceride was significantly decreased in olive oil and also triglyceride groups (P = 0.02 and 0.004, respectively). Conclusion: Overall, the effects of olive oil and grape seed oil were better than control group. However, we suggest the substitution of dietary lipids with olive oil because of its more beneficial effects. Registration number for clinical trial: IRCT2014070218329N1 registration code in Iran Clinical Trial site.
Highlights
Hyperlipidemia has a quite clear role in the etiology of coronary heart disease [1] [2]
Individuals were enrolled in the study included subjects 30 60 years of age, with at least one of imbalanced blood lipid indices [including total cholesterol (TC) ≥ 200 mg/dl, high density lipoprotein (HDL) ≤ 40 mg/dl, low density lipoprotein (LDL) ≥ 130 mg/dl and triglyceride (TG) ≥ 150 mg/dl], without a personal history of cardiovascular, hepatic and renal disease and intake of antioxidant supplements during the study
TG were significantly decreased after the intervention in GSO group (P = 0.004)
Summary
Hyperlipidemia has a quite clear role in the etiology of coronary heart disease [1] [2]. Some researchers are considered to replacing saturated and trans-fats with Mono Unsaturated Fatty Acids (MUFAs) containing oils such as olive oil [4]. They have emphasized the usefulness of olive oil and its correlation with lower prevalence of coronary disease. This study was designed to compare the effects of olive oil and grape seed oil on serum lipids and blood pressure in patients with hyperlipidemia in 2015. Olive oil intervention decreased systolic blood pressure significantly compared to grape seed oil group (P = 0.01). Conclusion: Overall, the effects of olive oil and grape seed oil were better than control group. Registration number for clinical trial: IRCT2014070218329N1 registration code in Iran Clinical Trial site
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