Effects of Olive Leaves Extract on Urea, Uric Acid and Creatinine Concentrations in Serum of Heat Stressed Male Rabbits

Abstract

The purpose of this study is to investigate the positive effects of olive leaves extract on the alteration of some renal function test (urea, uric acid and creatinine) in serum of male rabbits that have been reared under heat stress conditions. Thirty , New Zealand white male rabbits,(12-14 weeks old and 1500-2000 gm in weight) are individually caged, for 30 days. The animals are divided into six groups(5 animals for each) control group and 5 experimental groups (reared under heat stress environment). The first experimental group heat stressed only, the other two groups have received every day, 1000mg/kg/bw and 2000mg/kg/bw respectively of dried extract of olive leaves put in capsules and fed orally, the rest two groups have received 200 mg/ml and 400mg/ml respectively of aqueous extract of olive leaves with drinking water every day of the experiment. The results show a significant increase of urea, uric acid and creatinine levels in sera of heat stressed rabbits, while there is an improvement of these three parameters in the animal treated with the dried and aqueous extracts in concentration dependent manner. In conclusion, these results confirm the positive healthful properties of olive as anti-heat stress products.