Abstract
Summary Background & aims In lean subjects, free fatty acid (FFA) promotes gut hormone release, delays gastric emptying, and reduces appetite and energy intake more than an isocaloric load of triglyceride (TG). In obesity, the gastrointestinal sensitivity to lipids may be reduced. Therefore, we compared the effects of the FFA oleic acid and the TG olive oil on gut hormone secretion, gastric emptying, appetite, and energy intake in lean and overweight/obese subjects. Methods In a double-blind, randomized cross-over study, 8 lean and 13 overweight/obese healthy subjects were examined at two occasions to evaluate the effect of intragastric isocaloric loads of radiolabelled oleic acid or olive oil on gastric emptying, plasma CCK, PYY, and GLP-1 concentrations, appetite, and energy intake. Results In comparison to olive oil, oleic acid caused a slower gastric emptying (p Conclusion An intragastric load of FFA is followed by slower gastric emptying, increased CCK and PYY secretion, and a lesser subsequent energy intake than an isocaloric load of TG in both lean and overweight/obese healthy subjects.
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