Effects of nutraceuticals on sexual satisfaction and lower urinary tract symptoms in a cohort of young-old men.

Abstract

The aim of this study was to evaluate the effects of nutraceuticals containing multiple supplemental facts (Virherbe®/Rekupros®) on sexual satisfaction and lower urinary tract symptoms (LUTS) in young-old men. In an open-label trial, 40 males (mean age 66±13) with sexual disturbances and mild LUTS but without cognitive/motor impairment and clinical hypogonadism were enrolled. Sexual desire (SD; IIEF-SD domain) and satisfaction (Global Assessment Question; GAQ), the capacity to perform daily activities (evaluated by 6-min walking test [6MWT]), and International Prostate Symptoms Scores (IPSS) were evaluated before and after oral administration of 2 capsules/day of each supplement for 8weeks. The difference from baseline for SD was +2.6 (p<.05) and -4.2 points for IPSS (p<.05), with significance in subscales of urinary streaming/nocturia (p<.01), respectively; 6MWT increased from 507±44 versus 527±58meters (p<.001). GAQ scale-responses showed overall improvement in overall 75% population, with a significant improvement in QoL (p<.01). These changes returned to baseline at 1-month withdrawal follow-up. No adverse events were reported. These supplemental facts improved sexual desire, satisfaction with sex life, physical performance, and LUTS in young-old men, suggesting that they may be effective in patients in whom standard treatments are not suitable.