Abstract
Studies report that exposure of newborn to pain is predictive of global responses to pain in adults. The aim of the present study was to analyze the effects of noxious stimulation in neonatal phase in the sensory‐motor system of adult rats. Twelve male Wistar rats with 120 days of life were separated in 2 groups: pain group (n=6) and control group (n=6). The pain group was stimulated with a needle on the right paw, twice a day for 15 days. The control group was stimulated with a cotton swab on the right paw, twice a day for 15 days. To evaluate the hyperalgesia in both groups, we applied Von Frey monofilaments and a specific calibrated forceps; the evaluation of muscle strength of the hind paws was conducted through a special device (Grip Strength Meter). This device measures the grip strength of the hind paw in rats. Specific statistic tests were applied, and p value was considered significant when p less than 0.05. We observed that the pain group presented a hyperalgesia in the right hind paw and a decrease in muscle strength when compared to the control group. Our results suggest that noxious stimulation in the neonatal phase alters the sensorimotor system in the long term.
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