Abstract
To evaluate the efficacy and safety of intravitreal conbercept (IVC) for diabetic retinopathy (DR) compared with intravitreal triamcinolone acetonide (IVTA). PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, VIP database, and Wanfang database were searched from their earliest records to January 2020. We included randomized controlled trials (RCTs) evaluating the efficacy and safety of conbercept in DR patients compared with ITVA. Outcomes included the mean changes from the baseline in best corrected visual acuity (BCVA) score, central macular thickness (CMT), quality of life (QoL) over time, and the incidence of adverse events (AEs). A total of 19 RCTs involving 1,811 eyes were included in this meta-analysis. IVC might improve BCVA (WMD = 0.10, 95% CI (0.07, 0.12), P < 0.001) and reduce CMT (WMD = −102.5, 95% CI (−148.48, −56.53), P < 0.001) compared to IVTA. The incidence of AEs in patients receiving IVC was significantly lower than those receiving IVTA (RR = 0.29, 95% CI (0.21, 0.40), P < 0.001). Patients with IVC treatments acquired better self-care, mobility, social, and mental scores compared with IVTA (P < 0.001). Current evidence shows that IVC has better effects and safety than IVTA in treating DR, and it can significantly enhance the QoL of patients with DR.
Highlights
Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes and will result in visual impairments for patients with diabetes
A prevalence meta-analysis revealed that the global prevalence of DR, nonproliferative DR (NPDR), and proliferative DR (PDR) was 28%, 27%, and 6% in people with type 2 diabetes (T2D), respectively [4]. ese estimates are expected to rise further due to the increasing prevalence of diabetes and life expectancy of those with diabetes
Inclusion criteria included randomized controlled trial (RCT) of conbercept vs. triamcinolone in the treatment of DR; publication written in English or Chinese; outcome indicators which are the best corrected visual acuity, central macular thickness, the incidence of adverse events (AEs), and quality of life score
Summary
Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes and will result in visual impairments for patients with diabetes It has become the leading cause of blindness in working-age adults in developed countries [1, 2]. Alternatives for eyes that have a suboptimal response to vascular endothelial growth factor (VEGF) inhibitors include corticosteroids such as triamcinolone acetonide (TA). Intravitreal triamcinolone acetonide (IVTA) was the widely used medication for diabetic macular edema (DME) [5]. Newly established therapies for PDR and DR related macular edema is intravitreous injection of a vascular endothelial growth factor (VEGF) agency. According to the reports from American Academy of Ophthalmology (AAO) and the European Society of Retina Specialists (EURETINA), VEGF inhibitors are most effective to manage DME [6, 7]. Current evidence has not been systematically assessed; a systematic review and meta-analysis was conducted to evaluate the efficacy and safety of IVC in treatment of DR
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