Effects of Normocapneic Preoxygenation and Air Breathing during Vital Capacity Inhalation Induction with Sevoflurane on the Ventilation

Abstract

Background: Sevoflurane has been used to provide an inhaled induction by using a vital capacity breath, which is fast and has few side effects. We compared the clinical effects of a vital capacity inhalation induction (VCII) with sevoflurane in patients of preoxygenation or air-breathing before anesthetic induction. Methods: After IRB approval, patients were randomly assigned to receive preoxygenation ( group, 70 patients) or air breathing (Air group, 70 patients) via SIBI (Single Breath Induction) before VCII with 8% sevoflurane in 75% /(from primed circuit. The clinical characteristics were compared between two groups in respect to prolongation of breath holding after loss of consciousness (response to verbal command) and side effects (airway, hemodynamic, motor) during VCII. Results: ( group showed lower incidence (60.0% vs. 87.1%, P