Abstract
AbstractThe asphyxia resistance of the direct cortical response (DCR) and the electrocorticogram (ECG) was determined in noradrenaline treated and untreated newborn rabbits. The resistance of the untreated animals was similar to what has previously been found for the adult, the DCR being blocked within 3 1/2 min and the ECG within 2 min of asphyxia. After the ad ministration of noradrenaline the DCR became more resistant to asphyxia and could be evoked for 8–17 min. The ECG was not sustained by noradrenaline, and was blocked within 2 min of asphyxia as it was in the untreated animals.An increased ability of the DCR to withstand asphyxia has been described for the fetus. In view of the above mentioned effect of noradrenaline, it was proposed that this resistance of the fetal DCR to asphyxia is due to the fact that in the fetus asphyxia stimulates the release of noradrenaline from the preaortal paraganglia and the adrenal medulla. Possible mechanisms whereby the increased resistance of the DCR could be effected by noradrenaline were discussed.
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