Abstract
A transient outward current (I to) was elicited by depolarization in single smooth muscle cells isolated from guinea-pig vas deferens under whole-cell voltage-clamp conditions. The peak amplitude of I to was markedly decreased by over 80% within 10 s after application of 10 μM noradrenaline. When the pipette solution contained low molecular weight heparin (0.3–5 mg/ml), the inhibitory effect of 10 μM noradrenaline on I to was apparently reduced. Our results strongly suggest that the noradrenaline-induced suppression of I to is an event subsequent to Ca 2+ release and depletion of available Ca 2+ stored in the sarcoplasmic reticulum (SR) by myo-inositol 1,4,5-trisphosphate (InsP 3), an event which is blocked by low molecular weight heparin.
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