Abstract
The effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on gastroduodenal mucosal proliferation remains somewhat controversial. Experiments in rats have shown that acute administration of NSAIDs inhibits cell proliferation in the gastric mucosa while chronic administration of NSAIDs stimulates cell proliferation in gastric fundic and duodenal mucosa but has no effect in the gastric antral mucosa. Studies in humans have demonstrated that NSAIDs stimulate cell proliferation in the gastroduodenal mucosa. The stimulatory effect may be a compensatory reaction to mucosal injury and represent one of the mechanisms of gastric and duodenal mucosal adaptation to continued NSAID exposure. NSAIDs inhibit cell proliferation in the gastric mucosa at the ulcer margin in both rats and humans. This effect may account for the epidemiologic findings of delayed ulcer healing in patients taking long-term NSAIDs therapy. Since cell proliferation and renewal in gastroduodenal mucosa is one of the major mechanisms for the maintenance of mucosal integrity and enables repair of injury and ulcer healing, the effect of NSAIDs on cell proliferation in gastroduodenal mucosa is an important clinical issue.
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