Effects of Non-Cavity-Distorting Intramural Fibroids on IVF Outcomes in Patients With Recurrent IVF Failure: Does Myomectomy Change IVF Outcomes? [ID 2683663

Abstract

INTRODUCTION: Uterine fibroids are the most common benign smooth muscle tumors of the uterus. However, there is no consensus on whether myomectomy improves IVF success in women with non-cavity-distorting intramural fibroids. The aim of this study was to compare the IVF and pregnancy outcomes of women who had non-cavity-distorting intramural fibroids and underwent myomectomy versus women who had intramural fibroids, but did not undergo myomectomy. METHODS: This was a retrospective cohort study at Acibadem Maslak Hospital, IVF Center, between 2019 and 2020. The Acibadem University Ethical Committee approved the study protocol, which complied with the Declaration of Helsinki (2021-05/02). Data of 128 women aged between 25 and 43 years who have at least two intramural non-cavity-distorting fibroids of 2–6 cm in size were used. All patients had at least two IVF failures. The intervention group comprised women who decided to proceed to myomectomy before IVF (group 1, n=56). The control group was established women with intramural fibroids who reject myomectomy (group 2, n=71). RESULTS: In regard to IVF result parameters and perinatal outcomes, there was no statistically significant difference between the two groups. Between study groups, there were no statistically significant differences in the perinatal outcomes. Myomectomy surgery did not increase miscarriage and biochemical pregnancy rate (odds ratio [OR] 0.9; 95% CI, 2.8–3.7). CONCLUSION: Myomectomy does not substantially affect pregnancy or live birth rates according to the results of this study.