Abstract
AimTo analyse the anti-caries properties of nicomethanol hydrofluoride (NH) and the benefit of its combination with siliglycol, a coating agent.MethodsFluoride (F) uptake by dental enamel and synthetic apatite treated with NH was measured in vitro and compared to treatment with mineral fluorides. The addition of siliglycol was also tested. The effect of NH (as a mouthwash) on salivary pH was also investigated in healthy human subjects and compared to the effect of a placebo and of nicomethanol alone.ResultsIn vitro experiments showed a greater and faster F uptake on dental enamel or synthetic apatite treated with NH compared to sodium fluoride. F uptake was improved further by the addition of siliglycol. In healthy human subjects, pH reduction was strongly inhibited 5 min after two mouthrinses with NH. This effect was less pronounced but still statistically significant at 15 and 30 min (p < 0.05).ConclusionsNH was able to promote the fixation of F ions and strengthen the dental structure. Its combination with siliglycol further improved F uptake by the tooth and the control/inhibition of dental biofilm development.
Highlights
Despite a marked improvement in dental caries prevention over the last few decades, 60–90% of school children and nearly 100% of adults have dental cavities (Kimura et al 1983)
nicomethanol hydrofluoride (NH) impact on salivary pH was investigated in subjects who had taken the product in mouthwash form (250 mg Fper 100 mL solution)
F uptake was approximately 12 times greater on dental enamel and 19 times greater on synthetic apatite, with NH compared to NaF
Summary
Despite a marked improvement in dental caries prevention over the last few decades, 60–90% of school children and nearly 100% of adults have dental cavities (Kimura et al 1983). Dental caries bears a significant medical, social and economic cost in children, being one of the frequent reasons for absence from school (Rugg-Gunn 2013), and the commonest reason for general anaesthesia in young children when tooth extraction is required (Banoczy and RuggGunn 2013). The use of fluoride (F) toothpaste is considered to be one of the main contributing factors for the decrease in dental caries prevalence in children in both developed and developing countries (Bratthall et al 1996; Cury et al 2004; Marinho 2009; Marinho et al 2013; Rugg-Gunn and Banoczy 2013). Fluoride acts as an anti-caries agent by counterbalancing the mineral losses caused by acid production, mainly through the precipitation of fluoridated mineral components on teeth (Byeon et al 2016; Lata et al 2010; Tenuta and Cury 2010)
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