Effects of New Coordination Compounds of Ge, Sn, and Mg on Acute Generalized Convulsive Activity in Rats

Abstract

Neurotropic effects of new coordination compounds, germacit and stanmacit, were tested on models of acute generalized convulsive activity induced in rats by injections of pentylenetetrazol (PTZ, 40 mg/kg), picrotoxin (PT, 2.0 mg/kg), or kainic acid (KA, 15 mg/kg). The tested biologically active substances were injected in doses corresponding to 1/10, 1/20, 1/40, 1/80, or 1/135 of the calculated LD50. Germacit provided obvious anticonvulsive effects in the case of seizure activity induced by PTZ (in a dose of 1/80 LD50), PT, and KA (in doses of 1/40 LD50); the intensity of convulsive manifestations decreased significantly compared with analogous indices in control groups (P 0.05) but intensified PTZ- and KA-induced seizures (at 1/20 and 1/40 LD50, respectively; P < 0.05). The obtained data are indicative of the ability of new complex coordination compounds of germanium and tin with magnesium and citric acid to significantly control the excitability of cerebral structures involved in the generation of epileptiform activity.