Abstract
In order to ascertain whether the hypothermia induced by neutral aminoacids could depend upon a reduced oxygen supply to the brain, rats received, through a cannula chronically implanted into the lateral ventricle, glycine, GABA and taurine (20 μmol 250 g body weight). The brain levels of glucose, lactate, pyruvate and glycogen and those of glucose and lactate in the blood were determined during hypothermia. The concentration of these metabolites and the brain blood volume of cannulated animals were similar to those of unoperated controls. No consistent biochemical evidence of brain hypoxia was found after glycine, taurine and GABA administration. It is concluded that the effect exerted by the injection of neutral aminoacids into the CSF on thermoregulation is dependent on their direct action on nervous centres.
Published Version
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