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Abstract
The effects of centrally-active drugs on the incorporation of 14C from glucose into rat brain α-keto acids and amino acids were tested in vivo. Chlorpromazine lowered the incorporation into all metabolites tested and nembutal into all except alanine and pyruvate. Morphine lowered the radioactivity of the isolated γ-aminobutyrate and aspartate. No significant effects were observed after treatment with the stimulants iproniazid or amphetamine.
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