Abstract
1. A collection of neurotoxins, known to affect the sodium permeability of neuronal membranes, was analysed concerning their ability to perturb the high-affinity choline uptake system in membrane vesicles prepared from locust synaptosomes. 2. The initial transport rate as well as the overall capacity of choline accumulation was significantly reduced by toxins which affect Na +-flux and Na +-gradients (veratridine, scorpion toxin, sea anemone toxin). 3. This inhibitory effect was prevented by the channel blocker tetrodotoxin.
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