Abstract
The effects of intracerebroventricular injections of 18 nmol/10 μl of neurotensin, [ d-Tyr 11]neurotensin, or saline on operant responding for brain stimulation reward were investigated in Fischer 344 (F344) and Lewis (LEW) rats using the curve–shift paradigm. [ d-Tyr 11]neurotensin, but not neurotensin, decreased reward threshold in F344 rats while it increased thresholds in LEW rats. Both peptides suppressed maximal rates of responding; this effect was of greater magnitude and longer lasting in LEW than in F344 rats. These findings show that F344 and LEW rat strains are differentially sensitive to activation of central neurotensin receptors that modulate reward-relevant circuitry.
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