Abstract
BackgroundThe purpose of this study is to evaluate whether the changes in optically derived parameters acquired with a diffuse optical tomography breast imager system (DOTBIS) in the contralateral non-tumor-bearing breast in patients administered neoadjuvant chemotherapy (NAC) for breast cancer are associated with pathologic complete response (pCR).MethodsIn this retrospective evaluation of 105 patients with stage II–III breast cancer, oxy-hemoglobin (ctO2Hb) from the contralateral non-tumor-bearing breast was collected and analyzed at different time points during NAC. The earliest monitoring imaging time point was after 2–3 weeks receiving taxane. Longitudinal data were analyzed using linear mixed-effects modeling to evaluate the contralateral breast ctO2Hb changes across chemotherapy when corrected for pCR status, age, and BMI.ResultsPatients who achieved pCR to NAC had an overall decrease of 3.88 μM for ctO2Hb (95% CI, 1.39 to 6.37 μM), p = .004, after 2–3 weeks. On the other hand, non-pCR subjects had a non-significant mean reduction of 0.14 μM (95% CI, − 1.30 to 1.58 μM), p > .05. Mixed-effect model results indicated a statistically significant negative relationship of ctO2Hb levels with BMI and age.ConclusionsThis study demonstrates that the contralateral normal breast tissue assessed by DOTBIS is modifiable after NAC, with changes associated with pCR after only 2–3 weeks of chemotherapy.
Highlights
The purpose of this study is to evaluate whether the changes in optically derived parameters acquired with a diffuse optical tomography breast imager system (DOTBIS) in the contralateral non-tumor-bearing breast in patients administered neoadjuvant chemotherapy (NAC) for breast cancer are associated with pathologic complete response
The measurement of optically derived parameters in the affected breast is strongly dependent on the tumor location, and DOT suffers from low spatial resolution due to its nonlinear, ill-conditioned, and ill-posed inverse problem [9]
Using a priori information provided by an additional high-resolution anatomical imaging modality, such as magnetic resonance or X-ray, could improve spatial resolution and nullify the low-cost benefit associated with DOT techniques [10]
Summary
The purpose of this study is to evaluate whether the changes in optically derived parameters acquired with a diffuse optical tomography breast imager system (DOTBIS) in the contralateral non-tumor-bearing breast in patients administered neoadjuvant chemotherapy (NAC) for breast cancer are associated with pathologic complete response (pCR). The measurement of optically derived parameters in the affected breast is strongly dependent on the tumor location, and DOT suffers from low spatial resolution due to its nonlinear, ill-conditioned, and ill-posed inverse problem [9]. DOT quantitative measure from the contralateral breast could offer a nontumor dependent measurement to monitor NAC induced changes in the breast tissue and assess treatment outcome. Evaluation of optically derived parameters variation in the contralateral non-tumor-bearing breast following NAC has been previously analyzed [11]. Assessment of chemotherapy-related benefits for developing a newly detected breast cancer is still a challenge due to the absence of accurate quantitative metrics
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