Effects of Neck Radiation Therapy on Carotid Arteries in Patients with Head and Neck Carcinoma

Abstract

Background: Radiotherapy is a main treatment modality for cancers of the head and neck (HNC). However, it can cause a number of complications, including carotid artery damage.This study aimed to determine the effect of head and neck radiotherapy on carotid Doppler ultrasound findings in patients with HNC treated at Imam Hossein University Hospital. Materials and Methods: This research is a descriptive-longitudinal and prospective study conducted in 2022 on patients with HNC undergoing neck radiotherapy. In this study, before the initiation of radiotherapy, the patients underwent neck carotid artery Doppler ultrasound and various parameters including peak systolic velocity (PSV), end-diastolic velocity (EDV), internal carotid artery/common carotid artery (ICA/CCA) PSV, the number of plaques, intimal thickness, and percentage of carotid diameter stenosis, were recorded. The Doppler ultrasound was repeated six months later, addressing the same characteristics, and the collected data were compared. Results: Of 49 investigated patients, 32 (65.3%) were male (mean age=59.46 years). PSV, EDV, and ICA/CCA ratios showed no statistically significant difference 6 months following the completion of radiotherapy compared to the initial investigation. On the other hand, the percentage of carotid artery stenosis, the middle intimal membrane thickness, and the number of vascular plaques increased significantly (P<0.05). Conclusion: Carotid artery stenosis due to radiotherapy seems to be a common complication; however, radiotherapy probably has minimal effects on other ultrasound parameters of carotid arteries including EDV, PSV, and ICA/CCA ratio.