Abstract
Quorum sensing (QS) has emerged as a research hotspot in microbiology and medicine. QS is a regulatory cell communication system used by bacterial flora to signal to the external environment. QS influences bacterial growth, proliferation, biofilm formation, virulence factor production, antibiotic synthesis, and environmental adaptation. Through the QS system, natural products can regulate the growth of harmful bacteria and enhance the growth of beneficial bacteria, thereby improving human health. Herein, we review advances in the discovery of natural products that regulate bacterial QS systems.
Highlights
Until the 1980s, it was believed that bacteria individually grow and multiply with no communication between cells [1]
Two interrelated quorum sensing (QS) systems (Las and Rhl) and Pseudomonas quinolone signal (PQS) systems in Pseudomonas aeruginosa, SdiA, Lsr, and AI-3 QS are present in E. coli, whilst LuxS/AI-2 systems have been identified in Staphylococcus aureus
QS plays a vital role in bacterial biofilm formation, virulence factor regulation, and antibiotic formation
Summary
Until the 1980s, it was believed that bacteria individually grow and multiply with no communication between cells [1]. It is accepted that a common exchange of information exists between bacteria and that individuals of the same or different species compete or cooperate through quorum sensing (QS). We will discuss the underlying molecular mechanisms of QS and highlight its role in human health. We summarize the regulatory role of natural products in QS systems and probe their potential value in disease prevention, diagnosis, and disease treatment
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