Abstract
The use of prolonged respiratory support under the form of high-flow nasal cannula (HFNC) or nasal continuous positive airway pressure (nCPAP) is frequent in newborn infants. Introduction of oral feeding under such nasal respiratory support is, however, highly controversial among neonatologists, due to the fear that it could disrupt sucking, swallowing, and breathing coordination and in turn induce cardiorespiratory events. The recent observation of tracheal aspirations during bottle-feeding in preterm infants under nCPAP justifies the use of animal models to perform more comprehensive physiological studies on the subject, in order to gain further insights for clinical studies. The objective of this study was to assess and compare the impact of HFNC and nCPAP on bottle-feeding in newborn lambs, in terms of bottle-feeding efficiency and safety as well as sucking–swallowing–breathing coordination. Eight full-term lambs were instrumented to record sucking, swallowing, and respiration as well as electrocardiogram and oxygenation. Lambs were bottle-fed in a standardized manner during three randomly ordered conditions, namely nCPAP 6 cmH2O, HFNC 7 L/min, and no respiratory support. Results revealed that nCPAP decreased feeding duration [25 vs. 31 s (control) vs. 57 s (HFNC), p = 0.03] and increased the rate of milk transfer [2.4 vs. 1.9 mL/s (control) vs.1.1 mL/s (HFNC), p = 0.03]. No other indices of bottle-feeding safety or sucking–swallowing–breathing coordination were significantly altered by HFNC or nCPAP. In conclusion, our results obtained in full-term newborn lambs suggest that: (i) nCPAP 6 cmH2O, but not HFNC 7 L/min, increases bottle-feeding efficiency; (ii) bottle-feeding is safe under nCPAP 6 cmH2O and HFNC 7 L/min, with no significant alteration in sucking–swallowing–breathing coordination. The present informative and reassuring data in full-term healthy lambs must be complemented by similar studies in preterm lambs, including mild-to-moderate respiratory distress alleviated by respiratory support in order to mimic preterm infants with bronchopulmonary dysplasia and pave the way for clinical studies.
Highlights
Nasal respiratory support (NRS), especially nasal continuous positive airway pressure and high-flow nasal cannula (HFNC), has become the standard of care in convalescing preterm infants with bronchopulmonary dysplasia (BPD) and/ or cardiorespiratory events [1,2,3]
The prolonged use of NRS can delay the attainment of full oral feeding, which is a critical milestone for the preterm infant [4]
We have previously shown that bottle-feeding under nasal continuous positive airway pressure (nCPAP) is safe in both full-term [13] and preterm lambs [14] and is more efficient in preterm lambs [14], with no significant alteration in sucking–swallowing–breathing coordination
Summary
Nasal respiratory support (NRS), especially nasal continuous positive airway pressure (nCPAP) and high-flow nasal cannula (HFNC), has become the standard of care in convalescing preterm infants with bronchopulmonary dysplasia (BPD) and/ or cardiorespiratory events [1,2,3]. The prolonged use of NRS can delay the attainment of full oral feeding, which is a critical milestone for the preterm infant [4]. Current knowledge strongly suggests that early introduction of oral feeding accelerates feeding maturation in preterm infants [5, 6]. Initiation of oral feeding in preterm infants under NRS remains a controversial topic among neonatologists [9, 11, 12]
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