Abstract
The current study examined the effects of nanoscale electric fields generated by magneto-electric nanoparticles (MENs) on precancerous liver tissue. A total of30nm MENs synthesized by sol-gel method were tested in vitro on HepG2 cells and in vivo on liver cell dysplasia in mice, which were exposed to 50Hz 2mT for 2weeks, +/- MENs. MENs with alternating field (AF) reversed liver cells dysplastic features. In vitro cytotoxicity assay showed high lethal dose (LD 50) of 1.4mg/ml. We also report on the expression of alpha-fetoprotein and cytochrome C. MEN-generated nanoscale electric fields have significant biological effects on precancerous liver cells.
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