Abstract
Objective: This study aimed to determine the effects of nanocurcumin on cardiomyopathy, assessed by the expression of B-type natriuretic peptide(BNP) mRNA in heart tissue.Methods: Type 2 diabetic rats were induced with streptozotocin and nicotinamide. Nanocurcumin was orally administered (100 mg/kg/day)for 30 days. BNP-45 mRNA expression in the heart tissue was measured using quantitative reverse transcription-polymerase chain reaction andcalculated using the Livak method.Results: BNP-45 levels increased significantly (p<0.05) in diabetic rats compared with the normal group. Nanocurcumin treatment at a dose of100 mg/kg for 30 days significantly decreased BNP-45 expression levels (p<0.05) compared with diabetic rats without treatment.Conclusion: Nanocurcumin may be beneficial in inhibiting the progression of diabetic cardiomyopathy by suppressing the expression of BNP-45.
Highlights
Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia caused by insulin secretion abnormalities [1]
Our results indicate that B-type natriuretic peptide (BNP)-45 levels in diabetic rats were higher than in normal rats
This is likely because the diabetic rats had cardiomyopathy and the hypertrophic myocardium expressed BNP-45 to a greater extent [15]
Summary
Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia caused by insulin secretion abnormalities [1]. In Indonesia, the prevalence of diabetes increased from 5.7% of the overall population in 2007–6.9% in 2013 [2]. Treatments for hypertrophic cardiomyopathy are still being developed and include herbal medicines. One such herbal medicine is curcumin, an active substance obtained from Curcuma longa, which is an indigenous plant of Indonesia [9]. Previous studies have shown that curcumin has anti-inflammatory, antioxidant, and antiproliferative properties [9,10,11]. It may be promising as an adjunctive treatment of type 2 diabetes by inhibiting its progression [11]. A previous study has reported that the bioavailability of curcumin increases in the form of nanoparticles [12,13]
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