Abstract
Fipronil has been widely employed for crop protection over the past decade because of its low soil stability and insecticidal potency at modest application rates. The present study was designed to investigate the adverse effects of sub-acute exposure to 10 and 20 mg/kg/b. w. of Nano-Fipronil on biochemical blood profile and histological parameters in male rats according to the permissible limits of acceptable daily intake (ADI). The results hematological parameters indicated that Red blood cells (RBCs) and Hemoglobin(H.b) decreased in all treated groups compared with the control. While PLT and white blood cells (WBCs) was significantly increased in all treated groups compared with the control. The toxicity of effects of nano-fipronil pesticides leads to higher levels of liver function parameters (AST, ALT and ALP), kidney function (Blood urea and Creatinin and Uric acid) and Oxidative stress (MDA, GSH and CAT) results demonstrated highly significant differences (P≤0.05) in all groups treated compared with the control.
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