Abstract
In Experiment I, four groups of 24 rats each were presented with 200, 120-db tones at an 8-sec interstimulus interval (ISI) on each of 2 days following intraperitoneal injections of saline or 15 mg/kg N-N-Dimethyltryptamine (DMT). Separate groups were injected with either saline on both days or DMT on both days or saline on Day 1 and DMT on Day 2 or DMT on Day 1 and saline on Day 2. DMT depressed startle likelihood and impaired 24-h retention of startle habituation. The reduction in startle amplitude was monotonically related to the dose of DMT that was given over doses of 1, 2, 4, 8, and 16 mg/kg (Experiment II) and the impairment of retention was monotonically related to the dose of DMT that was given over doses of 1, 4, and 16 mg/kg (Experiment III). DMT did not impair retention of startle habituation if a 30-sec rather than an 8-sec ISI was used during training and testing (Experiment IV).
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