Abstract
The elevated T-maze (ETM) has been used to generate two defensive behaviors in the same rat, inhibitory avoidance and one-way escape, which have been related to generalized anxiety and panic, respectively. In the present study, we investigate the role of the amygdala on the modulation of these two behaviors. Male Wistar rats were tested in the ETM test 2, 7, or 14 days after bilateral N-methyl- d-aspartate (NMDA)-induced lesion of the amygdala. The animals were also tested in an open field for evaluation of motor performance. The results showed that animals tested 7 days after NMDA injection had impairment in the acquisition of inhibitory avoidance, indicating an anxiolytic effect. Lesion of the amygdala did not change one-way escape in any of the tested groups. These results provide further evidence for the involvement of the amygdala in the modulation of defensive behaviors that have been associated to generalized anxiety.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
