Abstract
We investigated the effects ofn-alkanols on the range and rate of the lateral diffusion of 1,3-di(1-pyrenyl)propane in the model membranes of total phospholipid fraction extracted from synaptosomal plasma membrane vesicles. n-Alkanols increased the range and rate of the lateral diffusion of 1,3-di(1-pyrenyl)propane in the bulk model membrane structures (inner+outer monolayers) and the potencies ofn-alkanols up to 1-nonanol increased by 1 order of magnitude as the carbon chain length increases by two carbon atoms. The cut-off phenomenon was reached at 1-decanol, where further increase in hydrocarbon length resulted in a decrease in the lateral diffusion. However, significant changes in the l′/l value were not observed by methanol (from 100 to 2500 mM), ethanol (from 25 to 800 mM), and 1-propanol (from 10 to 250 mM) over entire concentration.
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