Effects of Myrtus communis leaves decoction on biochemical and hematological disorders induced by Cypermethrin-chronic toxicity in rats.

Abstract

Background: Uncontrolled and an excessive uses of insecticides, in agriculture, will expose the human and animal health to a high risk of chemical toxicity. Objective: This study aimed to assess Myrtus communis (MC) effects against the toxicity induced by the Cypermethrin (CYP) in Wistar rat. Methods : The experimental period was 30 days, carried out on 50 rats, divided into 5 groups; group I (controls), group II orally administered with 20 mg / kg of CYP ( < 1/10 LD50) dissolved in corn oil (CO), a group III orally administered with CYP and treated with 1 mL of MC leaves decoction (50 g /L), a group IV receiving 1 mL MC and a group V received 1 mL CO. Results : A decrease in mean body weight was observed in group II (178 g) compared to group III (190.66 g). Biochemical parameters were insignificant. Mean blood glucose and urea levels were respectively 0.94 ± 0.03 and 0.65 ± 0.06 g / L (group II) and 0.72 ± 0.06 and 0.68 ± 0.05 g / L (group III). Furthermore, liver transaminase activities as GPT was 93 ± 38.7 (group II) and 36.6 ± 8.0 IU / L (group III) but GOT and ALP were respectively 188.3 ± 55.1 and 73.3 ± 47.7 (II) and 210.3 ± 33.8 and 207 ± 5.1 IU / L (III). The hematological parameters (blood cells and Hb) were respectively 6.16 ± 0.26 ×105 / mm3 and 13.52 ± 2.9 g / dL( II) and 7.37 ± 0.41×105 / mm3 and 14.14 ± 0.87 g / dL (III). Conclusion: The medicinal plant Myrtus communis showed limited and partial beneficial effects against Cypermethrine negative effects in animal model.