Effects of Mutation Number in Interferon Sensitivity Determining Region on Peripheral Blood CD4-Positive T Cell Subsets (TH1, TH2) in Chronic Hepatitis C Patients With Hepatitis C Virus Genotype 1b a and High Viral Load

Mie Shinohara,Michio Kogame,Kaori Kanayama,Katsuya Higami,Koji Ishii,Yasukiyo Sumino

doi:10.1016/s0016-5085(11)64027-4

Effects of Mutation Number in Interferon Sensitivity Determining Region on Peripheral Blood CD4-Positive T Cell Subsets (TH1, TH2) in Chronic Hepatitis C Patients With Hepatitis C Virus Genotype 1b a and High Viral Load

Mie Shinohara, Michio Kogame + Show 4 more

https://doi.org/10.1016/s0016-5085(11)64027-4

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Journal: Gastroenterology

Publication Date: Apr 21, 2011

#Number Of Amino Acid Mutations #Interferon Sensitivity Determining Region + Show 8 more

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Abstract

Background/aim The number of amino acid (AA) mutations in the interferon sensitivity determining region (ISDR) of NS5A is reported to affect the response to interferon (IFN) therapy in patients with chronic hepatitis C (CHC). The aim of this study was to clarify whether host immunity is influenced by the number of AA mutations in the ISDR.

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