Abstract
Objective To study the effects of MT(Metallothionein)overexpression on drug resistance in breast cancer cells.Methods Expression plasmid pBAcNeoMT ⅡA was transfected into breast cancer cell lineMCF 7/Adr cells.The drug resistance of the cells to cisplatin were detected by SRB experiment.Results Compared to the control cells,MCF 7/Adr cells transfected with MTⅡA cDNA showed enhanced resistance to cisplatin,The LD 50 increases from about 12 uM to approximately 30uM.Conclusion Overexpression of MT can increase resistance to cisplatin in breast cancer cells.
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