Abstract
This experiment was designed to test the effects of a 7 mg/kg dose of morphine sulfate on the extinction of a conditioned escape response in rats. Ten male albino rats were conditioned to escape a 30-v AC electric shock by running out of a start box, down a 3-ft runway and into a goal box. During extinction trials half the animals received 7 mg/kg of morphine sub-cutaneously (s.c.) and half received a subcutaneous (s.c.) injection of physiological saline as a placebo. The morphine group took a significantly greater number of trials to extinguish the escape response. It was concluded that morphine increased the resistance to extinction.
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