Abstract
Morphine injections in 16-day-old rats caused an increase in norepinephrine concentration in both superior cervical ganglion and iris after 1 h. Although the increase in the ganglion was blocked by naloxone pretreatment, the increase in the iris was not prevented. The morphine-induced increase did not require the presence of intact central connections. These findings demonstrate that morphine has direct effects on peripheral catecholaminergic systems in immature rats.
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