Abstract
The effects of intracellular and extracellular applications of morphine (in concentrations from 10 −3 to 10 −5M), leucine-enkephalin and methionine-enkephalin (10 −6 to 10 −8M) were studied in unidentified acetylcholine-sensitive dialysed neurons of a snail under voltage clamp. Morphine produced inward membrane currents, while enkephalins did not. Both morphine and enkephalins altered the effect of acetylcholine on postsynaptic acetylcholine receptors; intracellular application of these substances being much more effective than extracellular application. This suggested that opioid peptides take part in the regulation of cholinergic synaptic transmission.
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