Abstract
Monoamines (NE, DA) were studied for their effect on heterosynaptic facilitation of n-cholinergic synaptic transmission in identified giant neurons of the cerebral ganglion of Planorbis corneus. It was shown that NE and DA blocked n-cholinergic EPSP and facilitated acetylcholine potential evoked by ionophoretic acetylcholine application. The monoamines blocked heterosynaptic facilitation as well. Washing of the monoamines after blocking heterosynaptic facilitation evoked recovery and long maintenance of the synaptic facilitation. It is concluded that DA and NE release may be the mechanism for conducting the intensity and duration of the heterosynaptic facilitation in the natural activity of the central nervous system of molluscs.
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